Clinical Trials
Injectable Hydrogel (Investigational)

Vasalgel (Plan A)

A hydrogel injected into the vas deferens that blocks sperm; now in Phase 2 human clinical trials as Plan A by NEXT Life Sciences.

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Delivery ChannelClinical Trial Enrollment
Trial info
VP
How well it works
In trials

In clinical trials; efficacy data not yet available.

How was this measured?▾

Human efficacy data pending; Phase 2 trial underway. No published human efficacy results yet.

Why we rate it this wayPlan A Occlusion and Reversal System Feasibility Study (NCT07361120, Phase 2, recruiting); no published human efficacy data
Cost & insurance
Unknown

No cost to trial participants

Insurance CoverageVaries
Duration & reversibility
Lasts forLong-acting (multi-year target)
Reversibility
Reversible
STI ProtectionNo
The science
Active ingredientStyrene-alt-maleic acid (SMA acid) copolymer (Plan A formulation by NEXT Life Sciences)
How it works in the body

A styrene-alt-maleic acid (SMA acid) copolymer hydrogel is injected into the vas deferens, where it forms a soft filter that blocks sperm while letting fluid pass. It can be reversed with a dissolving injection. The polymer is distinct from the styrene-alt-maleic anhydride (SMA anhydride) copolymer used in RISUG.

FDA status
FDA statusClinical Trials
Used forClinical trial participation
Made byNEXT Life Sciences, Inc.
PrescriptionOTC
Side effects

No significant side effects reported in clinical literature.

Who shouldn't use this

No absolute contraindications identified.

The full picture

What to know about Vasalgel (Plan A)

Research and approval status

Vasalgel is an investigational medical device and is not yet approved for general use. It is not available by prescription or for sale. NEXT Life Sciences began Phase 2 human clinical trials in January 2026 under the name Plan A, following a successful delivery-device study completed in 2025. You can only get it by joining an active clinical trial. Organizations such as the Male Contraceptive Initiative can help you check whether you are eligible. Commercial availability is still several years away.

The studies

Clinical trials behind Vasalgel (Plan A)

The research that backs Vasalgel (Plan A), with links to the public trial records.

Phase 2Recruiting

Plan A Occlusion and Reversal System Feasibility Study

ClinicalTrials.gov: NCT07361120
View Trial Details
N/ACompleted

Plan A Novel Delivery Device Study

ClinicalTrials.gov: NCT06891729
View Trial Details
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An investigational polymer gel injected into the vas deferens, in Phase 3 trials in India. The original SMA-copolymer vas-occlusion technology related to Vasalgel/Plan A.

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