FDA Approved 
Prescription Medicine Hot Flash Pills
A daily prescription pill (neurokinin receptor antagonist) that blocks NK3 receptors in the brain to reduce hot flashes and night sweats.
2 productsNon-HormonalMenopause Relief
Compare non-hormonal options for hot flashes, vaginal dryness, sleep, and mood. Includes prescription pills, OTC supplements, and behavioral programs.
15 methods
FDA Approved 
Prescription Medicine SSRIs for Hot Flashes
A low-dose SSRI (paroxetine 7.5 mg) approved by the FDA for moderate-to-severe hot flashes.
1 product FDA Approved 
Prescription Medicine Vaginal Dryness Pills
SERM prescription pills that act like estrogen in some tissues and block it in others to relieve vaginal dryness and painful sex.
1 product FDA Cleared 
Topical Product Vaginal Lubricant
A non-hormonal gel applied at the time of sex to reduce friction and pain from vaginal dryness.
4 products FDA Cleared 
Topical Product Vaginal Moisturizer
Non-hormonal gels and creams inserted regularly to hydrate vaginal tissue and ease dryness from menopause.
4 products Established 
Injection Treatment Stellate Ganglion Block
An injection of local anesthetic into a nerve bundle in the neck that may interrupt hot flash signals for several months.
Off-Label 
Prescription Medicine Oxybutynin for Hot Flashes
An off-label anticholinergic prescription (oxybutynin) that reduces sweating and hot flashes by acting on temperature pathways.
1 product Off-Label 
Prescription Medicine Gabapentin for Hot Flashes
An off-label gabapentin prescription that may reduce hot flashes. Pregabalin is a related gabapentinoid but is not recommended for hot flashes.
1 product Supplement 
Daily Supplement Phyto-SERM Supplements
Plant-based supplements with SERM-like effects that may reduce hot flashes and night sweats. A non-hormonal method.
3 products Supplement 
Daily Supplement Pollen Extract
A dietary supplement made from Swedish flower pollen that may reduce hot flashes, available over the counter.
1 product Evidence-Based 
Mind-Body & Cycle Practice Clinical Hypnosis
A therapist-guided technique using focused attention and suggestion to reduce hot flash frequency and severity.
1 product Evidence-Based 
Mind-Body & Cycle Practice CBT for Hot Flashes
A structured, evidence-based talk therapy that teaches skills to manage the impact of hot flashes and night sweats.
Evidence-Based 
Mind-Body & Cycle Practice CBT for Insomnia
A structured talk therapy program that improves sleep during menopause by changing sleep habits and unhelpful thoughts about sleep.
Evidence-Based 
Mind-Body & Cycle Practice CBT for Mood
A structured talk therapy program to manage anxiety, depression, and emotional changes during menopause.
Evidence-Based 
Mind-Body & Cycle Practice Weight Loss
Losing excess weight through diet and exercise may reduce hot flashes, especially for women earlier in the menopause transition.
2,554 providers
Abbey Seufer
PA-C, MSCPFort Collins, CO 80525
Physician Assistant
Abisola Afolalu
MD,MSCPOrange, CT 06477-3559
Physician
Adanna Ikedilo
MD, MSCPFresno, CA 93720-3855
Physician
Adi Smolinsky
MD, MSCPLittle Silver, NJ 07739-1208
Physician
Frequently Asked Questions
Non-hormonal menopause relief includes FDA-approved prescription pills for hot flashes (neurokinin receptor antagonists such as fezolinetant and elinzanetant, and low-dose paroxetine), off-label prescription pills for hot flashes (gabapentin and oxybutynin), prescription pills for vaginal dryness and painful sex (ospemifene, a SERM), over-the-counter vaginal moisturizers and lubricants, talk-therapy programs (CBT for hot flashes, mood, and insomnia), clinical hypnosis, a nerve-block injection, behavioral weight loss, and over-the-counter supplements like Swedish flower pollen extract and red clover.
Yes. Several prescription pills and talk-therapy programs have been shown in clinical trials to reduce hot flashes and night sweats. The Menopause Society (NAMS 2023) gives Level I recommendations, its strongest tier, to fezolinetant, low-dose paroxetine and other SSRI/SNRIs, gabapentin, CBT, and clinical hypnosis.
They avoid estrogen and progestin. Every treatment still has its own side effects and contraindications, so check the method page for details.
Some options require a prescription, including neurokinin receptor antagonists (fezolinetant and elinzanetant), low-dose paroxetine, gabapentin, oxybutynin, and ospemifene. Others, including Swedish flower pollen extract and red clover supplements, are available over the counter.
Telehealth platforms, OB-GYNs, and menopause specialists can prescribe non-hormonal therapies. Each method page lists branded products and notes whether a prescription is required, so you can talk to your clinician about the right option.