FDA Approved 
Prescription Medicine Hot Flash Pills
A daily prescription pill (neurokinin receptor antagonist) that blocks NK3 receptors in the brain to reduce hot flashes and night sweats.
2 productsNon-HormonalMenopause Relief
Compare non-hormonal options for hot flashes, vaginal dryness, sleep, and mood. Includes prescription pills, OTC supplements, and behavioral programs.
15 methods
FDA Approved 
Prescription Medicine SSRIs for Hot Flashes
A low-dose SSRI (paroxetine 7.5 mg) approved by the FDA for moderate-to-severe hot flashes.
1 product FDA Approved 
Prescription Medicine Vaginal Dryness Pills
SERM prescription pills that act like estrogen in some tissues and block it in others to relieve vaginal dryness and painful sex.
1 product FDA Cleared 
Topical Product Vaginal Lubricant
A non-hormonal gel applied at the time of sex to reduce friction and pain from vaginal dryness.
4 products FDA Cleared 
Topical Product Vaginal Moisturizer
Non-hormonal gels and creams inserted regularly to hydrate vaginal tissue and ease dryness from menopause.
4 products Established 
Injection Treatment Stellate Ganglion Block
An injection of local anesthetic into a nerve bundle in the neck that may interrupt hot flash signals for several months.
Off-Label 
Prescription Medicine Oxybutynin for Hot Flashes
An off-label anticholinergic prescription (oxybutynin) that reduces sweating and hot flashes by acting on temperature pathways.
1 product Off-Label 
Prescription Medicine Gabapentin for Hot Flashes
An off-label gabapentin prescription that may reduce hot flashes. Pregabalin is a related gabapentinoid but is not recommended for hot flashes.
1 product Supplement 
Daily Supplement Phyto-SERM Supplements
Plant-based supplements with SERM-like effects that may reduce hot flashes and night sweats. A non-hormonal method.
3 products Supplement 
Daily Supplement Pollen Extract
A dietary supplement made from Swedish flower pollen that may reduce hot flashes, available over the counter.
1 product Evidence-Based 
Mind-Body & Cycle Practice Clinical Hypnosis
A therapist-guided technique using focused attention and suggestion to reduce hot flash frequency and severity.
1 product Evidence-Based 
Mind-Body & Cycle Practice CBT for Hot Flashes
A structured, evidence-based talk therapy that teaches skills to manage the impact of hot flashes and night sweats.
Evidence-Based 
Mind-Body & Cycle Practice CBT for Insomnia
A structured talk therapy program that improves sleep during menopause by changing sleep habits and unhelpful thoughts about sleep.
Evidence-Based 
Mind-Body & Cycle Practice CBT for Mood
A structured talk therapy program to manage anxiety, depression, and emotional changes during menopause.
Evidence-Based 
Mind-Body & Cycle Practice Weight Loss
Losing excess weight through diet and exercise may reduce hot flashes, especially for women earlier in the menopause transition.
2,554 providers
Alison Key
MD, JD, MSCPMarrero, LA 70072-3153
Physician
Amanda Olson
MD, MPH, MSCPMinneapolis, MN 55454-1462
Physician
Amanda Rohn
MD, FACOG, MSCPArlington, VA 22207
Physician
Amanda Swan
DNP, APRN, MSCPGlastonbury, CT 06033-4205
Nurse Practitioner
Frequently Asked Questions
Non-hormonal menopause relief includes FDA-approved prescription pills for hot flashes (neurokinin receptor antagonists such as fezolinetant and elinzanetant, and low-dose paroxetine), off-label prescription pills for hot flashes (gabapentin and oxybutynin), prescription pills for vaginal dryness and painful sex (ospemifene, a SERM), over-the-counter vaginal moisturizers and lubricants, talk-therapy programs (CBT for hot flashes, mood, and insomnia), clinical hypnosis, a nerve-block injection, behavioral weight loss, and over-the-counter supplements like Swedish flower pollen extract and red clover.
Yes. Several prescription pills and talk-therapy programs have been shown in clinical trials to reduce hot flashes and night sweats. The Menopause Society (NAMS 2023) gives Level I recommendations, its strongest tier, to fezolinetant, low-dose paroxetine and other SSRI/SNRIs, gabapentin, CBT, and clinical hypnosis.
They avoid estrogen and progestin. Every treatment still has its own side effects and contraindications, so check the method page for details.
Some options require a prescription, including neurokinin receptor antagonists (fezolinetant and elinzanetant), low-dose paroxetine, gabapentin, oxybutynin, and ospemifene. Others, including Swedish flower pollen extract and red clover supplements, are available over the counter.
Telehealth platforms, OB-GYNs, and menopause specialists can prescribe non-hormonal therapies. Each method page lists branded products and notes whether a prescription is required, so you can talk to your clinician about the right option.