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Methodology

Every number, approval date, and trial reference on this site is traced to a cited primary source. This page explains how we choose sources, handle conflicting evidence, and keep the data current.

Our core principle: no unsourced data

If a claim cannot be verified against an authoritative source, it does not appear on NonHormonal.com. We would rather show a missing field than an unverified number. When a data point is unknown or contested, we say so explicitly rather than filling the gap with a guess.

Method pages and product pages

Each method has a method page and one or more product pages. The method page is the source of truth for the full clinical picture: how it works, effectiveness, side effects, contraindications, clinical guidelines, cost context, and ongoing trials. Product pages are shorter and focus on brand-specific facts verified from FDA databases: active ingredient, manufacturer, approval date, and prescription status.

Clinical data belongs at the method level rather than duplicated across every brand. Side effects for a drug class come from each brand's FDA label, and merging them on a product page can be clinically misleading. Cost varies by retailer, insurance, and geography. What you read on a product page is always brand-specific and verifiable.

Where the data comes from

We use a fixed source hierarchy so the same kind of claim is always traced to the same kind of authority. Every cited source is freely accessible, with no paywall or login, so readers can verify anything we cite. We prefer PubMed over journal pages because PubMed is always free and contains the abstract with the headline numbers. We do not cite ACOG Practice Bulletins because they are paywalled.

  • Class-level contraceptive failure rates (condoms, diaphragm, spermicide, withdrawal, IUD, sterilization) come from the Guttmacher Institute contraceptive effectiveness table, built on the Trussell / Contraceptive Technology data. When Guttmacher does not list a method, we fall back to CDC efficacy tables, Cochrane reviews, Contraceptive Technology, WHO consensus statements, or peer-reviewed trials in that order.
  • Product-specific contraceptive efficacy (Paragard, Phexxi, Caya, Natural Cycles, and others) comes from the pivotal Phase 3 trial for that product, or the FDA label, cited via PubMed or DailyMed. We do not substitute a class-level number when a product-specific trial exists.
  • Menopause vasomotor symptom efficacy (fezolinetant, elinzanetant, paroxetine, oxybutynin, gabapentin, CBT, hypnosis, stellate ganglion block, pollen extract, phyto-SERM) comes from the pivotal randomized controlled trial, cited via PubMed. When only an observational study exists, we say so.
  • Clinical guidelines for contraception come from the CDC U.S. Medical Eligibility Criteria (2024) and Selected Practice Recommendations (2024). For menopause, they come from The Menopause Society (NAMS) 2023 Nonhormone Therapy Position Statement, with NICE NG23 as a complementary international source. For genitourinary syndrome of menopause, the NAMS 2020 GSM Position Statement is used.
  • FDA approval status and dates come from DailyMed or the Drugs.com approval history. Boxed warnings, REMS programs, and lab monitoring requirements match the current FDA label. Manufacturer identity is verified against DailyMed's Packager field, since drugs and devices change hands.
  • FDA device clearances (non-hormonal apps, femtech, and physical devices without a standard drug label) come from the FDA Medical Device Databases: PMA, De Novo, and 510(k) records.
  • Non-US regulatory approvals are verified against the official regulatory database (CDSCO for India). This applies only to the pill method (ormeloxifene), which is not available in the US; all other methods and products are FDA-approved, FDA-cleared, or on a US clinical-trial path.
  • Clinical trial registry numbers come from ClinicalTrials.gov for US and international trials, CTRI for India, and ANZCTR for Australia. Every registry ID is checked to confirm it resolves before it is added, and trial status is synced when it changes.
  • Cost data comes from Drugs.com price guides, manufacturer savings cards, or product pricing pages.

How we report effectiveness

Primary sources often report annual failure rates (for example, 13% typical failure for external condoms). We convert these to a consistent "effectiveness rate" format (87% effective), while preserving the original measurement context in the explanatory text alongside the number.

  • Only numbers a source directly reports. No derived percentages, no extrapolation across time periods. If a trial reports 6-month data, we publish 6-month data. If it reports an absolute reduction but not a percentage, we record the absolute reduction and leave the percentage empty.
  • The cited source must support the headline number. We do not cite a 2024 paper while using a number from a 1996 paper.
  • Most authoritative, not just newest. A higher-quality older study beats a lower-quality newer one. Guidelines are always the latest published edition.
  • Empty rather than misleading. When effectiveness varies by subgroup (parity for sponges and caps, body mass for lactational amenorrhea), we leave the percentage empty and explain the range. For investigational products with only animal data, we leave the percentage empty and label the findings as preclinical.

When two authoritative sources report different numbers, we prefer the higher-quality evidence type (randomized controlled trial over cohort, cohort over survey) and the source closer to the data (FDA label over secondary summary, primary trial over review). If quality is equal, the more recent source wins.

Effectiveness tiers

Every method has an effectiveness tier that gives an immediate "does this work?" signal without requiring a single percentage that may not exist.

Contraception tiers follow the CDC classification: Tier 1 (at least 99% effective, "Most effective"), Tier 2 (90 to 99%, "Moderately effective"), and Tier 3 (under 90%, "Least effective"). These boundaries are authoritative and we do not adjust them. When a product has its own typical-use number, the tier is derived automatically. When it does not, it inherits the tier of its method class.

Menopause tiers follow NAMS recommendation status: Level I ("Recommended"), Levels I-II or II-III ("Recommended, limited evidence"), or Not Recommended. The tier is independent of the numeric efficacy value: a treatment can be "Recommended" with a modest percentage, or "Recommended" with no percentage at all.

"Limited evidence" is honest, not a judgment of failure. It means we cannot verify efficacy for a specific product. It does not mean the product does not work. "In trials" is used for investigational treatments still in preclinical or early clinical stages with no published human efficacy data.

Safety, side effects, and contraindications

Side effects and contraindications are verified against the Contraindications and Adverse Reactions sections of the FDA label on DailyMed. For class-level methods, they are verified against CDC U.S. MEC or NAMS guidelines. We do not list speculative or unsourced safety details. This information appears on method pages, not product pages, because it applies to the method class rather than a specific brand.

Side effect and contraindication terms on method pages include explanatory tooltips where helpful, so readers can understand clinical language without leaving the page. Every term is checked against a clinical glossary to ensure the explanation matches.

Cost data

Cost figures are estimates, not guarantees. They go stale as prices change, so we always include context about what each figure represents: list price, cash price, with-savings-card, insurance copay, App Store price, and so on. Cost data appears on method pages, where it describes the method class as a whole. Product pages do not carry cost data because brand pricing varies by retailer, insurance, and geography.

Every cost entry has two labels that together tell you what you are looking at. The first describes how often the method is consumed or repurchased: per act, per month, per year, weekly, or one time. The second describes what the price covers: a single unit, a retail package, one billing period, or the total cost. This prevents a multi-dose package price from being mistaken for a single-dose price.

Editorial independence

Commercial relationships do not influence the data. Affiliate links, provider partnerships, and sponsorships never shape efficacy numbers, effectiveness tiers, approval dates, side effect listings, or editorial prose. The commercial call-to-action link on a product page is added only after the clinical content is finalized, and it is the only commercial surface on that page. Payments from partners, including commissions and referral fees, have no influence on which methods or products we list or how we describe them.

Keeping the data current

Each content file carries two dates that track its lifecycle. The "Last verified" date is when the data was last checked against its primary sources: efficacy numbers traced to the cited trial, FDA approval dates confirmed against DailyMed, trial statuses synced from ClinicalTrials.gov, and manufacturer names checked against the current label. The "Updated" date is when the content was last edited. "Last verified" is the primary trust signal and appears in the structured metadata that search engines use to assess content freshness.

The source hierarchy itself is reviewed to ensure the foundational guidelines (CDC U.S. MEC and SPR, The Menopause Society position statements, WHO fact sheets, and others) reflect the latest national or international consensus. When a newer edition supersedes a canonical source, we update the hierarchy first, then update every page that cites it.

Readers can report errors directly from any page. If you spot a wrong number, an outdated source, a broken link, or a provider listing that is no longer accurate, tell us. We review every report and fix cited data first.