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Compare Menopause Relief methods

Browse every side-by-side menopause relief comparison, or select methods from the list to compare your own combination.

Side-by-side comparison

  • Hot Flash Pills A daily prescription pill (neurokinin receptor antagonist) that blocks NK3 receptors in the brain to reduce hot flashes and night sweats.
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Method
Hot Flash Pills A daily prescription pill (neurokinin receptor antagonist) that blocks NK3 receptors in the brain to reduce hot flashes and night sweats.
Second method

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EfficacyHot Flash Pills Recommended

Recommended by the Menopause Society for symptom relief.

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CostHot Flash Pills $25–$618 monthly Insurance: Varies—
DurationHot Flash Pills Daily pill (ongoing)—
ReversibilityHot Flash Pills Reversible—
STI protectionHot Flash Pills No—
How it worksHot Flash Pills

Blocks neurokinin-3 (NK3) and/or neurokinin-1 (NK1) receptors in the hypothalamus to interrupt the temperature-regulation pathway that triggers hot flashes and night sweats.

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PrescriptionHot Flash Pills Required Telehealth Prescription—
Side effectsHot Flash Pills
  • Elevated liver enzymes (requires monitoring)
  • Abdominal pain
  • Diarrhea
  • Insomnia
  • Back pain
  • Hot flush
  • Headache
  • Somnolence, dizziness, and fatigue (dual NK1/NK3 antagonists such as elinzanetant)
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Who shouldn't use thisHot Flash Pills
  • Known cirrhosis (NK3 antagonists such as fezolinetant)
  • Severe renal impairment or end-stage renal disease (NK3 antagonists such as fezolinetant)
  • Concomitant use of CYP1A2 inhibitors such as fluvoxamine (NK3 antagonists such as fezolinetant)
  • Pregnancy (dual NK1/NK3 antagonists such as elinzanetant)
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