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Compare Menopause Relief methods

Browse every side-by-side menopause relief comparison, or select methods from the list to compare your own combination.

Side-by-side comparison

  • Phyto-SERM Supplements Plant-based supplements with SERM-like effects that may reduce hot flashes and night sweats. A non-hormonal method.
  • Second method

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Method
Phyto-SERM Supplements Plant-based supplements with SERM-like effects that may reduce hot flashes and night sweats. A non-hormonal method.
Second method

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EfficacyPhyto-SERM Supplements Not recommended

Not recommended by the Menopause Society.

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CostPhyto-SERM Supplements $30–$35 per package Insurance: Varies—
DurationPhyto-SERM Supplements Daily supplement (ongoing)—
ReversibilityPhyto-SERM Supplements Reversible—
STI protectionPhyto-SERM Supplements No—
How it worksPhyto-SERM Supplements

Phyto-SERMs are plant-derived, nonsteroidal compounds that bind to estrogen receptors. Isoflavones, the main group, bind more strongly to estrogen receptor beta than to estrogen receptor alpha and can act as estrogen agonists or antagonists. For DT56a (Femarelle), a tofu-derived extract, tissue-selective activity (estrogen-like in bone and vascular tissue but not in the uterus) has been shown mainly in studies of rats and cultured cells.

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PrescriptionPhyto-SERM Supplements Not required Direct-to-Consumer (Physical)—
Side effectsPhyto-SERM Supplements
  • Nausea (soy products)
  • Bloating, constipation, or diarrhea (soy products)
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Who shouldn't use thisPhyto-SERM Supplements
  • Soy allergy (soy-based products)
  • Concomitant use of prescription SERMs or hormone therapies (requires doctor consultation)
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