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Compare Menopause Relief methods

Browse every side-by-side menopause relief comparison, or select methods from the list to compare your own combination.

Side-by-side comparison

Method
Vaginal Dryness Pills

Vaginal Dryness Pills

SERM prescription pills that act like estrogen in some tissues and block it in others to relieve vaginal dryness and painful sex.
Second Method

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Efficacy68.3% had symptom improvement

Around 68% had symptom improvement.

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Cost$0–$340 /monthly

Insurance: Usually

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DurationDaily pill (ongoing)—
ReversibilityReversible—
STI ProtectionNo—
How it works

SERMs bind to estrogen receptors and act like estrogen in some tissues (bone, vagina) while blocking estrogen in others (breast, uterus). This tissue-selective action can treat menopause symptoms without systemic estrogen.

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PrescriptionRequired Prescription required—
Side effects
  • Hot flashes (paradoxical in some users)
  • Vaginal discharge
  • Muscle spasms
  • Hyperhidrosis
  • Headache
  • Vaginal hemorrhage
  • Night sweats
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Who shouldn't use this
  • Known or suspected estrogen-dependent neoplasia (e.g., breast or endometrial cancer)
  • Active DVT, pulmonary embolism, or a history of these conditions
  • Active arterial thromboembolic disease (e.g., stroke, myocardial infarction) or a history of these conditions
  • Undiagnosed abnormal genital bleeding
  • Known or suspected pregnancy
  • Hypersensitivity to ospemifene or any ingredient
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