Gabapentin for Hot Flashes
vs
Phyto-SERM Supplements

A side-by-side comparison of two menopause relief methods — efficacy, cost, how they work, and who shouldn't use them.

Side-by-side comparison

Method
Gabapentin for Hot Flashes

Gabapentin for Hot Flashes

An off-label gabapentin prescription that may reduce hot flashes. Pregabalin is a related gabapentinoid but is not recommended for hot flashes.
Phyto-SERM Supplements

Phyto-SERM Supplements

Plant-based supplements with SERM-like effects that may reduce hot flashes and night sweats. A non-hormonal method.
Efficacy45% reduction in hot flash frequency

Around 45% reduction in hot flash frequency.

Not recommended see details

Not recommended by the Menopause Society.

Cost$4–$30 /monthly

Insurance: Usually

$30–$40 /monthly

Insurance: No

DurationDaily pill (ongoing)Daily supplement (ongoing)
ReversibilityReversibleReversible
STI ProtectionNoNo
How it works

Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which may calm overactive temperature regulation and reduce hot flash frequency. Pregabalin binds the same target but NAMS 2023 does not recommend it for hot flashes.

Phyto-SERMs are plant-derived compounds that bind to estrogen receptors in target tissues such as the brain and bones, but not in uterine or breast tissue. This tissue-selective activity may relieve hot flashes and night sweats without stimulating breast or uterine tissues.

PrescriptionRequired Prescription requiredOTC No prescription / OTC
Available Products1 product3 products
Side effects
  • Drowsiness
  • Dizziness
  • Fatigue
  • Headache
  • Weight gain
  • Peripheral edema
  • Mild headache
  • Transient nausea
Who shouldn't use this
  • Hypersensitivity to gabapentin or any ingredient
  • Severe renal impairment (requires dose adjustment)
  • Severe soy allergy
  • Concomitant use of prescription SERMs or hormone therapies (requires doctor consultation)