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Pill
vs
Spermicide

A side-by-side comparison of two birth control methods — efficacy, cost, how they work, and who shouldn't use them.

Side-by-side comparison

Method
Pill

Pill

No non-hormonal birth control pill is FDA-approved in the US. Ormeloxifene (centchroman) is approved and used in India.

Spermicide

Spermicide

A chemical gel, foam, or film inserted into the vagina before sex to disable sperm, available over the counter.

EfficacyLimited evidence see details

Limited evidence: no verifiable efficacy data available.

79% typical use

Least effective: under 90 out of 100 people successfully prevent pregnancy per year.

CostContact provider

Insurance: Varies

$1–$3 /per unit

Insurance: Varies

DurationWeekly pill (ongoing)Single use (effective for 1 hour; duration varies by formulation, check product label)
ReversibilityReversibleReversible
STI ProtectionNoNo
How it works

Ormeloxifene (centchroman) is a selective estrogen receptor modulator (SERM) that prevents pregnancy by inhibiting implantation of a fertilized egg in the endometrium. It does not suppress ovulation and does not contain estrogen or progestin. It is not FDA-approved in the US.

A chemical (usually nonoxynol-9) immobilizes or kills sperm on contact. Inserted into the vagina before sex.

PrescriptionRequired Prescription requiredOTC Over-the-counter
Available Products1 product2 products
Side effects
  • Menstrual irregularities (delayed or altered periods; common, about 8-12% of users)
  • Headache
  • Nausea
  • Abdominal discomfort
  • Breast tenderness
  • Vaginal or penile irritation
  • Increased risk of UTI
  • Allergic reaction (rare)
Who shouldn't use this
  • Polycystic ovarian disease (PCOS)
  • Recent history of jaundice or hepatic impairment
  • Renal impairment
  • Cervical hyperplasia or chronic cervicitis
  • Pregnancy
  • Hypersensitivity to ormeloxifene
  • Sensitivity to nonoxynol-9
  • Active vaginal irritation or infection
  • High risk of HIV exposure (frequent use may increase transmission risk)