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Pill
vs
Vasectomy

A side-by-side comparison of two birth control methods — efficacy, cost, how they work, and who shouldn't use them.

Side-by-side comparison

Method
Pill

Pill

No non-hormonal birth control pill is FDA-approved in the US. Ormeloxifene (centchroman) is approved and used in India.

Vasectomy

Vasectomy

A permanent outpatient procedure that blocks the vas deferens so sperm cannot enter the semen.

EfficacyLimited evidence see details

Limited evidence: no verifiable efficacy data available.

99.85% typical use

Most effective: over 99 out of 100 people successfully prevent pregnancy per year.

CostContact provider

Insurance: Varies

$0–$3,500

Insurance: Usually

DurationWeekly pill (ongoing)Permanent
ReversibilityReversiblePermanent
STI ProtectionNoNo
How it works

Ormeloxifene (centchroman) is a selective estrogen receptor modulator (SERM) that prevents pregnancy by inhibiting implantation of a fertilized egg in the endometrium. It does not suppress ovulation and does not contain estrogen or progestin. It is not FDA-approved in the US.

A clinician cuts, seals, or blocks the vas deferens so sperm cannot mix with semen during ejaculation. The body absorbs the sperm, and the semen remains normal in appearance and volume.

PrescriptionRequired Prescription requiredOTC Procedure (in-person)
Available Products1 productNo branded products yet
Side effects
  • Menstrual irregularities (delayed or altered periods; common, about 8-12% of users)
  • Headache
  • Nausea
  • Abdominal discomfort
  • Breast tenderness
  • Mild pain or swelling for a few days
  • Bruising or bleeding at the site
  • Sperm granuloma (small lump, usually harmless)
  • Chronic post-vasectomy pain syndrome (rare, 1-2%)
Who shouldn't use this
  • Polycystic ovarian disease (PCOS)
  • Recent history of jaundice or hepatic impairment
  • Renal impairment
  • Cervical hyperplasia or chronic cervicitis
  • Pregnancy
  • Hypersensitivity to ormeloxifene
  • Uncertainty about future fertility desires
  • Active local or systemic infection
  • Bleeding disorder