How it works
Vaginal pH modulators are prescription gels that keep the vagina acidic enough to disable sperm. The FDA-approved gel contains lactic acid, citric acid, and potassium bitartrate. You insert it with a pre-filled applicator up to one hour before each act of vaginal sex, and each act needs its own dose. It is not effective if applied after sex. In studies, it kept vaginal pH in the normal acidic range in the presence of semen and reduced sperm motility.
Research and approval status
The FDA approved a vaginal pH modulator gel for contraception in 2020. In the AMPOWER Phase 3 trial, it was 86.3% effective with typical use over seven cycles. The trial’s primary endpoint was the typical-use rate. It does not protect against STIs.
Where to get it
You need a prescription, which you can get through telehealth or a local clinician. You use the gel on demand, so there is no daily routine. Some users report vaginal burning or an increased risk of urinary tract infections. Check our provider directory for clinics near you that prescribe this gel.
